National surveys were used to assess the distribution and characteristics of malignancy related deaths among HIV patients in 2010, and compared them to 2000 and 2005. Cancer is the leading cause of mortality in the HIV infected patients studied. The risk of malignancies, including non-AIDS-related cancers, is higher in HIV patients than in the general population. Smoking is reported to be the primary risk factor in non-AIDS-related cancer, particularly lung cancer. Based on the 728 deaths (median age at death was 50) reported in 2010, the proportion of deaths attributed to malignancies significantly increased from 28% in 2000, 33% in 2005, and 36% in 2010. Non-AIDS-related cancer deaths increased from 11% in 2000, 17% in 2005, and 22% in 2010. Compared to 2000 (16%), there was significant decrease in deaths attributed to AIDS-defining cancers in 2010 (9%). The proportion of respiratory cancer increased from 5% in 2000 to 6% in 2005 and 11% in 2010. Lung cancer was found to be the most common cancer-related cause of death in 2010. The study emphasized the need to optimize cancer prevention, screening and therapeutic management in HIV-infected patients in order to reduce mortality due to malignancy.
Summary by Stephen Karpiak PhD, ACRIA and NYU College of Nursing
Vandenhende, et al. “Cancer-related causes of death among HIV-infected patients in France in 2010: evolution since 2000.” PloS ONE 10.6 (2016): e0129550. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4470800/